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What is CJC-1295 Whitout DAc ?

It’s crucial to understand that “CJC-1295 Without DAC” is the common name, but it can be misleading. The accurate and specific name for this peptide is CJC-1295 (Modified GRF 1-29).

  • The Confusion: The original CJC-1295 was a research peptide with a Drug Affinity Complex (DAC). The DAC was designed to bind the peptide to albumin in the bloodstream, creating a long-lasting release that could maintain elevated GH levels for over a week from a single injection.

  • “Without DAC”: Researchers and the peptide community realized that the continuous elevation of GH from the DAC version was unnatural and potentially problematic. They then isolated the core active part of the molecule—Modified GRF (1-29)—and marketed it as “CJC-1295 Without DAC” to distinguish it from the long-acting version.

In short: When people refer to CJC-1295 Without DAC, they are almost always talking about Modified GRF (1-29).

Mechanism of Action: A Pure Growth Hormone Releaser

CJC-1295 (Modified GRF 1-29) is a synthetic analog of the body’s natural Growth Hormone-Releasing Hormone (GHRH), specifically the fragment from amino acids 1-29.

  • Natural GHRH’s Role: Your hypothalamus naturally releases GHRH, which travels to the pituitary gland and binds to its receptor, signaling it to produce and release a pulse of Growth Hormone (GH).

  • CJC-1295’s Action: This peptide is a more stable and potent version of natural GHRH. It binds to the GHRH receptor on the pituitary, providing a strong and clean signal to release GH.

The key modification (the addition of a Norleucine amino acid) protects it from being broken down too quickly by the enzyme DPP-4, giving it a longer half-life than natural GHRH—about 30 minutes compared to just a few minutes.

The Synergistic “Secretagogue Stack”

CJC-1295 (Modified GRF 1-29) is rarely used alone. Its true power comes from its synergistic combination with a GHRP (Growth Hormone-Releasing Peptide) like GHRP-6, GHRP-2, or Ipamorelin.

This combination is often called a “Secretagogue Stack” and is considered the gold standard in peptide therapy for mimicking the body’s natural GH pulsatility.

How the Synergy Works:

  • CJC-1295 (GHRH Analog): Acts as the “amplifier” or “priming agent.” It prepares the pituitary gland, making it more sensitive and ready to release a large burst of GH.

  • GHRP (Ghrelin Mimetic): Acts as the “trigger” or “stimulus.” It provides the strong signal to initiate the GH release.

Using them together creates a much larger, more natural-looking GH pulse than using either one alone. The combined effect is greater than the sum of its parts.

Effects and Uses of CJC-1295 Whitout DAc

By stimulating natural, pulsatile GH release, the effects are broad and include:

  • Increase in Lean Muscle Mass: Anabolic, muscle-building effects.

  • Reduction of Body Fat: Enhanced lipolysis (fat breakdown).

  • Improved Skin Health & Elasticity: Increased collagen synthesis.

  • Enhanced Wound Healing and Tissue Repair: Faster recovery from workouts and injuries.

  • Improved Sleep Quality: Deeper, more restorative sleep.

  • Increased Bone Density:

  • Boost in Energy and Sense of Well-being:

Dosage, Administration, and Protocol

There is no FDA-approved dosing. The following is based on common research and community consensus.

  • Standard Dosing: The typical dose for CJC-1295 (No DAC) is 100 mcg per injection.

  • Synergistic Dosing: It is almost always paired with a GHRP at a 1:1 ratio (e.g., 100 mcg CJC-1295 + 100 mcg Ipamorelin).

  • Administration: Subcutaneous (SubQ) injection.

  • Frequency: 1-3 times per day. The most common and effective times are:

    • First thing in the morning (on an empty stomach)

    • Post-workout

    • Right before bed (at least 2 hours after your last meal to avoid food-induced GH suppression)

Side Effects and Risks

CJC-1295 (No DAC) is generally considered to have a very clean side effect profile because it mimics the natural GHRH pathway so closely.

  • Injection Site Reaction: Redness, itching, or a small bump are common due to the peptide’s structure. This usually subsides within 15-30 minutes.

  • Flushing or Tingling: A mild, temporary sensation.

  • Headache: Occasionally reported.

  • Water Retention: Rare and usually mild.

  • The “DAC” Confusion Risk: The most significant risk is accidentally purchasing the long-acting CJC-1295 with DAC, which leads to non-physiological, continuous GH release and carries a much higher risk of side effects like acromegaly-like symptoms, insulin resistance, and joint pain. Always confirm you are getting “CJC-1295 WITHOUT DAC” or “Modified GRF (1-29)”.

Key Takeaways

  • CJC-1295 Whitout DAc = Modified GRF (1-29). It is a synthetic GHRH analog.

  • Its primary benefit is creating a powerful, synergistic GH pulse when stacked with a GHRP (like Ipamorelin or GHRP-2).

  • It has a short half-life (~30 min) and is designed to mimic the body’s natural pulsatile GH release, making it much safer than the long-acting “with DAC” version.

  • It is a research chemical, not an approved drug, and carries the standard risks associated with unregulated peptides.

Additional Information

Optional specification

5mg*10vials, 10mg*10vials

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